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Although PEGPH20 combined with albumin-bound paclitaxel/gemcitabine did not improve overall survival in metastatic patients, losartan combined with FOLFIRINOX showed promising results in locally advanced PDAC [142, 143]

Glycyrrhizin, a terpenoid compound, improves HPH-induced right ventricular systolic pressure elevation and right ventricular hypertrophy, reduces pulmonary inflammation, and delays PVR by inhibiting HMGB1

Importantly, IGF-1 activity is influenced not only by total growth hormone levels but by the timing and amplitude of growth hormone pulses