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Stores sit mainly in the liver and last years, so deficiency develops slowly and quietly, which is precisely why it gets missed

The decrease in these hormone levels impacts women's daily lives and can lead to hot flashes, sleep disturbances, and an increased risk of osteoporosis

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Randomization was stratified by response to pemetrexed in combination with cisplatin induction therapy (CR or PR versus SD), disease stage (IIIb versus IV), and ECOG PS (0 versus 1)