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van der Hulst RRWJ, Meyenfeldt MFV, Soeters PB

Several technical factors have been investigated in an attempt to reduce the rate of PEH recurrences: PEH sac excision, the method of crural closure, the addition of an esophageal lengthening procedure, and the addition of a gastropexy

To this end, the protective effect of NMN could be a potential strategy to prevent these side effects

The increased PEP also inhibited phosphofructose kinase (encoding by pfk ) activity, which was responsible for the decreased glycolytic flux and the down regulation of the glycolytic activities [33]

To further enhance their analgesic effects, nanozymes have been demonstrated to balance endogenous antioxidants and inhibit pro-inflammatory cytokines

Mechanistically, it could be because PI3K activates AKT via downstream molecules, and AKT activates mTOR by phosphorylation