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W., Rock, C

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doi:10.1016/j.bbrc.2014.01.056

In a high-oxidative-stress environment rich in superoxide, NO is rapidly converted to pro-ferroptotic ONOO

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Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions