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A healthy, unstressed cell maintains a vast majority of its glutathione pool in the reduced state, typically sustaining a GSH-to-GSSG ratio of greater than 10:1, and often up to 100:1 in the cytosol

Meanwhile, as an important feature of the tumor microenvironment, inflammation is closely related to oxidative stress, which can also promote tumor drug resistance

Theranostics 2(8):769 Safarkhani M, Kim H, Han S, Taghavimandi F, Park Y, Umapathi R, Jeong Y, Shin K, Huh YS (2024) Advances in sprayable sensors for nerve agent detection

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This approach has demonstrated positive therapeutic prospects in animal models of certain neurological diseases

During the ER stress regulation, ATF4 activates UPR target gene, which encodes proteins necessary for antioxidant reaction and amino acid synthesis and transport [120]