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IECs are capable of phagocytosing bacteria and can also sequester and neutralize bacterial toxins

Rodriguez-Farre and R

When this organ faces malfunction or disease, the implications can be far-reaching, affecting numerous bodily processes

In PKD1-deficient cells, 4-HNE, as a signaling molecule, promotes cell proliferation and aggravates cyst growth by activating AKT, S6, STAT3, and RB (Fig

The stress response is initiated and controlled by two hormonal systems, which lead to the production of catecholamines (such as adrenaline and noradrenaline, and their precursor dopamine) by the hypothalamus-sympathetic-chromaffin (HSC) axis, and corticosteroids (mainly cortisol) by the hypothalamus-pituitary-interrenal (HPI) axis (Wendelaar Bonga, 1997, 2011