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The decreased expression of SIRT1/PGC-1 has been observed in the deoxycorticosterone acetate (DOCA)-salt induced hypertension rat model treated with the 5/6 nephrectomized mouse model and H 2 O 2 -treated NRK-52E cells

A pilot study revealed that PARP-1 knockout mice exhibit impaired liver regeneration and reduced hepatocyte proliferation

This susceptibility stems from reduced basal GSH levels caused by impaired plasma membrane expression of SLC7A11

10.1016/j.celrep.2019.03.054 Cell Rep

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In comparison with probiotics, betaine alone can directly protect liver, adipose, intestinal barrier integrity and restore the commensal microbiota and SCFA production (33) and thus in comparison functions to prevent liver disease and other inflammatory condition without any adjunct probiotic use