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Discussion We conducted a meta-analysis integrating 154 metabolites from baseline and on-therapy timepoints across independent epidemiological and interventional cohorts encompassing diverse geographic sites, tumor histologies, and treatment modalities, applying DynForest 36 to address the challenge of modeling high-dimensional, time-dependent metabolomics data in small-sample settings

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To form an ester bond, a hydrogen from the glycerol's hydroxyl group and a hydroxyl group from the fatty acid's carboxyl group are removed to form a molecule of water