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the catheters were flushed with heparinized saline before and after blood sample collection and filled with heparin-glycerol locking solution (6 mL glycerol, 3 mL saline, 0.5 mL gentamycin (lOOmg/mL), 0.5 mL heparin (10,000 u/mL)) when not used for more than 8 h

Animal studies show low acute toxicity, but human safety data remain limited,,

Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

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Many autistic children are drawn to water, making it a highly motivating therapeutic medium

Behavioral assessment: cerebellar ataxia scoring A protocol for the rapid and sensitive quantification of disease in rodent models of cerebellar ataxia (63) is described in Table 1