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(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

One single nucleotide substitution predicts the substitution of the highly conserved Arg89 by Cys (BPGM Creteil I)

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However, one can argue that altering the coding gene at one locus gets compensated by the simultaneous loss of non-coding gene(s) at the same position