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Nature, 2014

Pale or Jaundiced Skin: A lack of B12 may lead to anaemia, giving the skin a pale or slightly yellowish tone

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Furthermore, given that the patients with high pre-treatment CD38 levels on MM cells have a better response to Daratumumab monotherapy, high CD38 expression on MM cells seems satisfactory to maximize the clinical efficacy such as the combination treatment of CD16F158V CD38 low NK cells and Daratumumab [120]