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However, the extent of ROS generation significantly differed that posttreatment inhibited the ROS generation by 58.4%, whereas pretreatment suppressed the generation of ROS by 90.5%

Free Radic Biol Med 43:319331 Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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However, plant GPXs are classified in the pyridoxine protein group due to an efficiently reduction of peroxide via the thioredoxin regenerating system (Iqbal et al., 2006

Concurrently, mitochondrial dysfunction and oxidative stress exacerbate inflammaging via mitochondrial reactive oxygen species (mtROS), which not only trigger NLRP3 inflammasome activation and IL-1 maturation but also suppress SIRT1 deacetylase activity, further reinforcing NF-B-driven inflammatory cascades 43