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The incorporation of nanomaterials may enhance the effectiveness of the chemotherapeutic, delay the development of chemoresistance, and maybe able to overcome the systemic and intracellular barriers through differential properties of temperature, electrical, photo-responsive, piezoelectric, pH, and redox

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Therapeutically, this raises two complementary possibilities: (1) SQOR-high tumors may exhibit enhanced mitochondrial ferroptosis resistance through maintained CoQ 10 H 2 and sulfur-based RTAs and (2) tumors with altered sulfur/selenium metabolism may reveal synthetic vulnerabilities when SQOR-linked defense is impaired

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