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According to Aydin et al

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We examined the 6-month mortality rate as an outcome measure

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Specifically, incorporating the 4-1BB costimulatory signaling motif into the CAR design activates signaling pathways that include the NIK/non-canonical NF-B pathway, which enhances T cell persistence and antitumor efficacy [171]

For instance, leptin and adiponectin contribute to body weight regulation, while TNF-, IL-6, and IL-1 are associated with local inflammation resulting from obesity