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Mechanisms of EGCG in neuroprotective disorder of microglia and gut microbiota in neuro-immune communication

In addition, a binding site for nucleolin, a nucleic acid-binding protein that has been implicated in stabilizing transcripts (332), was identified in the 3 UTR of the GPx-1 transcript

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First-line interventions include: Dietary modification : Adopting a balanced, calorie-controlled diet rich in vegetables, fruits, whole grains, and lean proteins whilst limiting processed foods, saturated fats, and added sugars Regular physical activity : Aiming for at least 150 minutes of moderate-intensity exercise weekly, which improves insulin sensitivity independent of weight loss Alcohol reduction : Even in NAFLD (non-alcohol-related), minimising alcohol consumption supports liver health Management of comorbidities : Optimising control of diabetes, hypertension, and dyslipidaemia through appropriate medications For patients with type 2 diabetes and NAFLD, medications such as pioglitazone (a thiazolidinedione) have shown benefits for liver health in addition to glycaemic control, though this is an off-label use in the UK and carries risks including fluid retention, weight gain and potential heart failure exacerbation

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