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4.2.2 Potential impact of specific gut microbiota on ferroptosis in OA 4.2.2.1 Prevotella copri: contradiction between human OA enrichment and mouse model protection Recent research on OA has revealed that the endogenous bacterium Prevotella copri (P

Yasmeen R, Zahid B, Alyas S, Akhtar R, Zahra N, Kouser S, et al

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It operates through a relatively small number of interconnected biochemical systems: mitochondrial energy metabolism membrane lipid structure antioxidant defense networks methylation chemistry neurotransmitter signaling mineral dependent enzyme activity RELATED: OPEN PART 2 OF THIS ARTICLE TO READ LATER When a nutrient participates in one of these systems, the body can actually use it

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Moreover, loss of DJ-1 impairs microglial function through heightened inflammatory response to -syn, reduced -syn uptake due to lipid raft disruption, and defective autophagy-lysosomal degradation (Nash et al., 2017)