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Testicular hypoplasia was seen in dogs treated for 1 year at 12.5 times the maximum daily dose

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A disrupted gut sends pro-inflammatory signals upstream

Baghel K, et al

Nelson DB, Mehran RJ, Mitchell KG, Van Haren RM, Mena GE, Woodard T, Correa AM, Hofstetter WL, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Antonoff MB , Roth JA, Heymach JV, Rice DC