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Thiamidol in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase

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Mechanism & Research Background Melanotan II is a synthetic cyclic lactam analog of the -MSH core sequence, constrained by a lactam bridge between its Asp and Lys residues to resist enzymatic degradation and increase receptor affinity

mSOD1 Tregs co-cultured with mSOD1 adult microglia repressed cytotoxic microglial factors such as NOX2 and iNOS through an IL-4-mediated mechanism