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NTDs include various malformations, such as lesions of the brain (e.g., anencephaly, encephalocele) or lesions of the spine (spina bifida), which are devastating and usually incompatible with life (57)

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[12] Damage to the liver is not due to the drug itself but to a toxic metabolite ( N -acetyl- p -benzoquinone imine (NAPQI)) produced by cytochrome P-450 enzymes in the liver