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Free Radic Biol Med (2019) 131:35669

As the valproic acid dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and/or phenytoin may be affected [seeDrug Interactions (7.2)]

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Thus, GSH and ATF4 levels in CML cells are the markers to indicate JMF4073 sensitivity and determine the selection of GSH blocker for the combination with JMF4073 in therapy