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The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls

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However, there are few reports of serious side effects

If results are weak into the remodelling phase and starting dose was sub-3.2 mg, a dose increase and protocol modification may be warranted