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Although the precise mechanisms underlying KDs effects in PD remain incompletely understood, evidence suggests that the diet can modulate glucose utilization in the brain, neurotransmitter metabolism, insulin signaling, oxidative stress, neuroinflammation, and ion channel activity, particularly potassium channels [20]

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Absolute bioavailability compares bioavailability of a drug administered via any non-intravenous route (e.g., oral, intramuscular, transdermal) to the bioavailability of the same drug given intravenously (IV)

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These sequencesfrom ferroptosis to inflammation mediated by released DAMPsexplain the ferroptosis arm of the vicious cycle