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Therefore, as shown in Table 2, various types of nanoparticles including nanoemulsions/microemulsions, lipid nanoparticles, vesicular nanocarriers, polymeric nanoparticles, and gold nanoparticles were utilized to enhance skin permeation, improve drug solubility, increase photostability, control the drug release profile, induce longer drug deposition within the skin layers, and therefore enhance the clinical effectiveness of the therapeutic options for melasma treatment

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GDH1 expression is significantly upregulated in tumor samples from patients with advanced breast or lung cancer, resulting in the accumulation of fumarate

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