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Your health care provider (typically your primary care doctor or a neurologist) may inquire about the frequency and severity of the pain, as well as what appears to trigger it and what causes it to feel better or worse

In the rodent studies reported to date it has generally been described as tolerated across the dose ranges examined, but comprehensive controlled human safety data do not exist, so conclusions about tolerability in people remain unconfirmed

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doi: 10.3389/fnins.2012.00182

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She was treated with high-dose intramuscular vitamin B12 (2,000 g/day), resulting in rapid clinical and hematologic improvement