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However, various internal and external factors can disrupt this balanced distribution, causing melanin to accumulate in specific areas and creating the characteristic dark spots associated with hyperpigmentation

Folate and B12 deficiencies cause the body to produce less glutathione and elevate unmetabolized homocysteine (6)

We exploited the secured C-terminal modification site of each peptide, as discussed above, and prepared fluorescently labelled macrocycles aML5-Fluo, aMD4-Fluo and aMD5-Fluo via the -amino group of a lysine residue in a tag peptide at the C-terminus (Supplementary Table 2 and Supplementary Fig

Even though the liver can store it, vitamin B12 must still be regularly consumed

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