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10.1186/s13229-024-00585-6 305 WinkL

Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations

It requires: verifying the chemical compatibility between the peptides (cross-stability), optimizing the ratio to maintain the bioactivity of each component, individual quality control of each peptide before co-formulation, and validating the stability of the lyophilized mixture over time

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Therefore, SLC7A11 overexpression may promote tumor growth/survival but once the tumor is established, SLC7A11-high tumors are more sensitive to glucose or glutamine deficiency in the tumor microenvironment ( Figure 2 )

Software Fiji ImageJ 41,42