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While preparing this manuscript for submission, a study based exclusively in in vitro assays was published showing that the addition of 25 M BSO or the use of tools to delete GCLC inhibits the growth of Burkitt lymphoma cell lines under 2D culture conditions [42], seemingly suggesting a comparable susceptibility to glutathione starvation between TICs and differentiated tumor cells

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126 A double-blind, placebo-controlled trial of magnesium with malic acid showed no benefits during the 4-week blinded phase with a low dose of 150 mg magnesium and 600 mg malic acid, but showed significant benefits in the severity of pain and tenderness scores in an open-label extension of the study after 2 and 6 months, with a dose in excess of 400 mg magnesium and 1600 mg malic acid