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The copper component serves as a cofactor for lysyl oxidase and other enzymes involved in collagen cross-linking and extracellular matrix formation

Moreover, during the purification stage, high-speed centrifuges are also used to fractionate and separate components depending on size and density

That is the mechanistic case for the blend in one paragraph and it is exactly why the two are described as complementary rather than redundant

54, 55 Specifically, plasma samples were deproteinated by adding 50% v/v of freshly prepared 10% metaphosphoric acid (MPA), centrifuging at 2000 g for 2 min and then the supernatant stored at 20 C until assaying

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