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control, and 72 h vs.36 h under PEG treatments, respectively (Fig

Picard M, Turnbull DM

iNOS activity is activated immediately after ionizing radiation (within 2 h) via NF-B pathway (58), thereby inducing NO production, which may then interact with radiation-induced superoxide to form peroxynitrite (56)

Phytochem Rev 75:127 Rock CD (2017) Phenylpropanoid metabolism

Once desired lightening is achieved, dermatologists recommend transitioning to lower-frequency use, typically 3 to 4 times weekly rather than daily, combined with consistent sunscreen use and monthly professional treatments if desired