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Importantly, REDEFINE 1 also showed that a significant proportion of participants achieved 25% body weight reduction a threshold that, in clinical terms, represents the kind of weight loss previously achievable only through bariatric surgery

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Acknowledgements We apologize to the researchers who were not referenced owing to space limitations

Collectively, these antioxidants alleviate renal anemia by reducing premature erythrocyte death, prolonging erythrocyte lifespan in circulation, and addressing the oxidative stress imbalance inherent to CKD, making them promising adjuvant therapeutic agents alongside conventional EPO or iron supplementation

Specifically, certain miRNAs can target and regulate iron metabolism-related proteins or directly inhibit the expression of System Xc and GPX4, thereby promoting ferroptosis (Fan et al., 2021