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An important aspect of our work is that HNE is primarily an endogenous product of lipid peroxidation (16, 17)

10.1016/j.tins.2006.06.002

Fujihashi, K

J Immunol 1984: 133:969-974 Hermanson GT, Mallia AK, Smith PK

qtot -0.636 5 OG311 1 ful O5 5 -0.636 15.9994

The ongoing phased replacement of older, more toxic NRTIs (e.g., d4T, AZT) with newer agents such as tenofovir alafenamide (TAF) and integrase strand transfer inhibitors (INSTIs), which have minimal impact on mtDNA, is a critical step in mitigating iatrogenic mitochondrial harm (164166)