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doi: 10.1016/j.bbi.2018.03.004 178 WuTDejanovicBGandhamVDGogineniAEdmondsRSchauerSet al

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In response to starvation, FOXO3 expression is upregulated leading to the induction of autophagy by promoting the formation of autophagosomes, and FOXO3 knockdown reduces autophagosomes in skeletal muscles (Mammucari et al

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Single molecule/FRAP experiments 17 directly observed importin shuttling through NPCs, revealing transient interactions with FG repeats and a characteristic transport dwell time

Methods: Patient 1: A 64yearold male patient presented with lower limb weakness