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In contrast, 12/15-LOX, found in endothelial cells, VSMCs, macrophages, and platelets, oxidizes arachidonic acid to 12-HETE and 15-HETE, leading to LDL oxidation, foam cell formation, and endothelial dysfunction

10.7759/cureus.70435 122 NishidaY.KamataniN.MiyamotoT

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EVs of ADSCs origin up-regulated the gene expression of glutamine synthetase in hepatocytes while down-regulating the expression of GLS2, which interfered with glutamine metabolism as well as the progression of hepatic fibrosis [129]

32, 49464959 10.1128/MCB.00761-12 [DOI] [PMC free article] [PubMed] [Google Scholar] 99.Karlsson, H.K.R., Zierath, J.R., Kane, S., Krook, A., Lienhard, G.E

Notably, we found in 24monthold lenses that this VEGFA expression in nucleated lens fibers is maintained in the aged lens (Fig 1H)