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To mitigate these limitations, models should be developed and validated on large, multi-center, and demographically diverse cohorts, with systematic bias-audit frameworks and prospective external testing prior to clinical deployment

VLN cigarettes have 95% less nicotine than the traditional cigarette and have been proven to greatly reduce nicotine consumption

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Even six months before the scheduled Spring 1990 test marketing and before costs were incurred for ads or promotions, the cost of the project had exceeded $1.4 million

With six seasons of the show, that adds up to roughly 18,000 cigarettes over the series run