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have shown that the cube shaped nanocomplexes of polydopamine functionalized AuNPs and magnetic ferric chloride nanoparticles conjugated via hyaluronic acid polymer using carbodiimide chemistry bind specifically to CD44 receptors for initiating receptor mediated endocytosis process and upon binding they emit strong fluorescence signal allowing fluorescence imaging of breast cancer cells [193]

Factors upstream of PARP-1, such as JNK1/2 and ERK1/2, may also regulate cell death following PARP-1 inhibition (108)

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However, tumor resistance to cisplatin still remains a huge challenge

Mol Cancer Ther 7 (10): 32473255

390 RegueiroJ.Snchez-GonzlezC.Vallverd-QueraltA.Simal-GndaraJ.Lamuela-RaventsR.Izquierdo-PulidoM