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doi: 10.1126/sciimmunol.aax0352 45 LiuXWangYBauerATKirschfinkMDingPGebhardtCet al

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Biochemistry 39 , 516528, doi:10.1021/bi991620j (2000)

At baseline, 76% of patients had high IFN regulated gene expression

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The more severe stages, particularly mild cognitive impairment and dementia, often accompanied by progressive deficits, predominantly manifest in elderly individuals ( Insulin and Insulin-like Growth Factor receptors (IGF) receptors, akin to insulin-like peptides, are expressed in neurons and glial cells, with insulin receptor (IR), insulin-like growth factor 1 (IGF1R), and insulin-like growth factor 2 (IGF2R) signaling through their respective receptors well-expressed in regions such as the hippocampus, striatum, hypothalamus, cerebral cortex, and olfactory bulb (Wijesekara et al., 2018)