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For this reason, IV NAD+ therapy may be administered to potentially enhance memory, improve concentration, improve the ability to focus, enhance brain regeneration, and improve overall neurological function

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doi: 10.3389/fcell.2025.1698296 Received 03 September 2025 Revised 02 December 2025 Accepted 04 December 2025 Published 08 January 2026 Volume 13 - 2025 Edited by Dongxu Wang, Jiangsu University of Science and Technology, China Reviewed by Mohamed Taha Moutaoufik, Mohammed VI Polytechnic University, Morocco Sudipta Ashe, Minutia Inc., United States Updates Copyright 2026 Ruchko, Chernysheva, Sokolov, Starinnov, Sabirov and Vasiliev

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By forcing proximity between the target protein and the E3 ligase, PROTAC induces proximity-driven polyubiquitination of the POI, i.e., the proximity forced by the PROTAC results in the transfer of the ubiquitin units from the E3 ligase to the POI 23

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Oxidative stress in Rett syndrome: natural history, genotype, and variants

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