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& Micinski, D

Transfection of the oncogene c-RAF in rat parotid epithelial cells results in loss of TJ integrity, downregulation of occludin and claudin-1, and altered ZO-1 and E-cadherin localization

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These observations are best explained by hypothesizing that the patients hydrolyze intracellular oligopeptides properly but have a defect in the transport of cationic amino acids across the basolateral membrane