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Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

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These combinatorial treatment approaches enhance the CAR-T cell safety and efficacy by modifying the tumor microenvironment, optimizing the CAR structure, bridging the CAR-T cells to the tumor cells, possibly targeting the multiple antigens, bypassing the tumor-immune escape mechanisms, and limiting the toxicity of CAR-T cell therapy (Fig

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These changes correlate with increased GSH levels and decreased ACSL4 expression, thus mitigating ferroptotic cell death in IL-1stimulated chondrocytes and preserving cartilage integrity (187)