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We focus our discussion on derangements in glucose metabolism, cell respiration/mitochondrial function and changes to ketone and lipid metabolism/oxidation to emphasize potentially novel biomarkers for clinical outcome prediction and intervention and offer new insights into possible underlying mechanisms from preclinical research of TBI pathology

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It is predominantly localized in mitochondria and functions as a sulfurtransferase that converts 3-mercaptopyruvate, which is produced from cysteine by cysteine aminotransferase (CAT), into pyruvate (Figure 2d) (Nag et al., 2006