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Two complementary paths are promising: (1) established postbiotic formulations - purified, chemically characterized metabolites, or metabolite mixtures that are formulated for topical or local use (gels, mouth rinses, vaginal suppositories, device coatings)

Future preclinical work may probe combinations with incretin-based agents or -oxidation enhancers to define mechanistic complementarity

Think of it as turning down the flow of incoming calories

All FDA-approved AMPs were discovered in Gram-positive soil bacteria, and 98% of known AMPs also come from natural sources (skin secretions of frogs and toxins from different species)

Finally, they were kept in 10 mL M9 medium overnight (16 h) under rotation at 35 rpm (Multiple-Axle-Rotating-Mixer RM10W-80V, CAT) to allow animals to hatch

pneumoniae [33]