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Further testing of individuals with ASD and CESLAC ruled-out secondary causes of fatty-acid oxidation deficiencies including multiple carboxylase deficiencies, zinc deficiency, elevated copper, generalized hyperlipidemia or hypercholesterolemia, and hypoglycemia

By exploring gut microbiome in subjects characterized by TMAO producer phenotypes, we identified 39 operational taxonomy units that were highly correlated to TMAO productivity, including Emergencia timonensis , which has been recently discovered to convert -butyrobetaine to TMA in vitro