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The structurally simplified Ang IV peptidemimetic 16 was almost as active as Ang IV as an IRAP inhibitor while 17 was five-fold and 18 and the open chain 19 were 20-fold less active (Figure 5)

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Due to the unique anatomical relationship between the CNS and the nasal cavity, relatively quick along with easy access for nanodrugs to the brain could be realized via intranasal administration

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Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus

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The pineal gland regulates circadian rhythm and produces melatonin, which governs sleep, immune function, and antioxidant defense

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