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In patients already taking 120mg of oral furosemide per day, the nephron must be blockaded at other levels through the addition of a second diuretic (HCTZ, ACZ, or MRA)

Luo JL, Hammarqvist F, Andersson K

Under pathological conditions, they may initially exert neuroprotective effects, yet prolonged activation often results in metabolic disturbances and neurotoxic gliotransmission, highlighting their dual role in CNS pathology and their potential in therapy [293]