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Up to now, only one specific pharmacological treatment option for patients suffering APAP-induced liver injury (AILI) exists: the administration of high doses of the n-acetylcysteine (NAC), which is the only FDA approved antidote for clinical use against APAP overdose

[] Lead exposure was responsible for 1.06 million deaths and 24.4 million disability cases worldwide in 2019, [] and lead poisoning has been ranked as the most important environmental health risk to United States children by the Centers for Disease Control

In selected cases with drug-resistant pain or poor tolerance, surgery should be considered

Cantin et al., 2007