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2021ZD0203900 and 2022ZD0212600), the Department of Science and Technology of Zhejiang Province (No

Authors' contributions Melissa de Almeida Corra Alfredo: Design and planning of the study, drafting and editing of the manuscript, and approval of the final version of the manuscript

Discussion REDOX biology is a novel and promising area of research for understanding the etiology and development of therapeutic interventions for several brain conditions

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Further studies are required to understand the molecular targets involved in methotrexate- induced hepatotoxicity, as well as to translate into therapeutic approaches

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