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Most researchers find the simplest approach is to reconstitute the full vial and accept some waste during the low-dose weeks

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While these model systems provide valuable insights into liver function and drug metabolism, they fail to mimic the intricate three-dimensional (3D) architecture, cellular heterogeneity, and zonation observed in the native liver

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Semaglutide (Ozempic), approved in 2017, extended the half-life to approximately one week through a C18 fatty diacid modification with enhanced albumin affinity