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Modifiable risk factors in knee osteoarthritis: treatment implications. Rheumatology international 39.7 (2019): 1145-1157

severe infections or sepsis, irregular blood vessel surface (vasculitis, artificial heart valve), or, rarely, disseminated intravascular coagulation or DIC (a serious complication of overwhelming infections, traumas, burns, or pregnancy)

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Some vendors publish batch-specific Certificates of Analysis from independent labs