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Current depressive symptoms and lifetime diagnosis To account for the presence of both lifetime and current depression simultaneously, a variable was constructed with the physicians diagnosis and the PHQ-9 cutoff with four levels: no current symptoms & no lifetime diagnosis (PHQ-9 sum score 10 10

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Since PARP-1 activation is a prerequisite to initiate the parthanatos pathway 23 , we treated HBE cultures with the selective PARP-1 inhibitor BMN673 currently in clinical trials for cancer treatment 27 and exposed the cells to mainstream smoke