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Arvat E, Camanni F, Ghigo E

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Some electron carriers in the electron transport chain, such as coenzyme Q, will directly transfer electrons to oxygen, causing oxygen molecules to undergo single-electron reduction and thereby generating a large amount of O 2

Oxidative stress can cause abnormal expression of various inflammatory markers, resulting in mitochondrial dysfunction and aberrant cellular energy metabolism, further increasing the joint burden and exacerbating joint damage [6, 7]

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Results Cryo-EM structure determination of OCTN2 To determine the structure of OCTN2, we overexpressed full-length human OCTN2 in HEK293F cells and isolated the transporter using a GFP-nanobody purification strategy 28